Abstracts from the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012
Abstract
According to recent long-term studies is schizophrenia a chronic disorder with a high risk of poor outcome in terms of symptoms and social functioning and possibly also progressive brain alterations.The relapse rate is high and each relapse can induce further aggravations, both in psychosocial as well as in neurobiological terms.Thus acute and long-term treatment with the highest degree of effectiveness should be provided to the patients in acute and long-term treatment.It is of special interest that some schizophrenia susceptibility genes and chromosomal abnormalities, particularly examined for early onset populations, are associated with premorbid neurodevelopmental abnormalities.Recent MRI imaging studies on patients at risk for schizophrenia showed a specific pattern of brain alterations which is predictive for the development of a full-blown psychosis.In addition to neurodevelopmental disorder, a neuroprogressive brain disorder is increasingly being hypothesized to explain a further decline especially in the poor outcome subgroup of schizophrenic patients.Results from genetic research, especially recently from the genomewide association studies hint at disturbances of neurodevelopment/ neuroplasticity as well as immunological and glutamatergic processes as part of the complex aetiopathogenesis.The relevance of immunological processes is especially supported by results indicating immunological parameter alterations in patients suffering from schizophrenia and especially…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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