Personality Genetics and Health in Super-Seniors
Abstract
Healthy aging is a complex phenotype, and genetic factors that contribute to long term good health are not well understood.Longevity and health are associated with lifestyle choices.Behaviour is governed by personality; therefore, variation in personality-related genes may affect healthy aging.Five candidate genes involved in the physiology of personality and personality disorders were identified from the literature: COMT, DRD4, MAOA, SLC6A4, and TH.Single nucleotide polymorphisms and variable number of random repeat polymorphisms were genotyped in DNA from 493 European-ancestry healthy oldest-old and 431 European-ancestry middle-aged controls.Tests for allelic associations were conducted, with stratification by sex.No associations remained significant after correction for multiple tests.Variants tested in these candidate genes were not associated with long-term good health in this sample.Either genetic variation in these genes does not influence healthy aging, or true effects exist that are too small to be detected in this study.
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