106 The Significance of Testosterone Levels and the Efficacy of Tadalafil 5 mg Once Daily for Lower Urinary Tract Symptoms
Abstract
Testosterone (T) regulates nitric oxide synthase and is necessary to achieve an optimum response to PDE5 inhibitors for erectile dysfunction. Recently, tadalafil was found to be effective for treating lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). We studied the relative importance of the T level in patients with LUTS and determined whether the T level predicts the response to tadalafil 5 mg once daily for LUTS/BPH. After a 4-week washout period, 122 men older than 45 years without (n=62, T level ≥300 ng/dl) and with (n=60, T level <300 ng/dl) hypogonadism were given tadalafil 5 mg once daily for 12 weeks. We assessed its impact and the severity of LUTS/BPH using the International Prostate Symptom Score (IPSS) and BPH Impact Index (BII) and IPSS quality-of-life (IPSS-QoL) subscores. Safety was assessed using treatment-emergent adverse events. The severity of LUTS/BPH was similar in the men with and without hypogonadism. Tadalafil significantly reduced LUTS/BPH from baseline in both groups (IPSS –5.4 vs –5.1, both p < 0.05; IPSS voiding subscore –3.4 vs –3.4, both p < 0.05; IPSS storage subscore –2.0 vs –1.7, both p < 0.05; without and with hypogonadism, respectively). Tadalafil also significantly improved the quality of life from baseline in both groups (IPSS-QoL –1.0 vs –0.7, BII –1.3 vs –1.2; both p < 0.05, without and with hypogonadism, respectively). Comparing the groups, the magnitude was significantly larger for the IPSS storage…
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