PD25-08 the significance of testosterone levels and the efficacy of tadalafil 5 MG once daily for lower urinary tract symptoms
Abstract
You have accessJournal of UrologyBenign Prostatic Hyperplasia: Evaluation & Markers1 Apr 2014PD25-08 THE SIGNIFICANCE OF TESTOSTERONE LEVELS AND THE EFFICACY OF TADALAFIL 5 MG ONCE DAILY FOR LOWER URINARY TRACT SYMPTOMS Hyun Jun Park and Nam Cheol Park Hyun Jun ParkHyun Jun Park More articles by this author and Nam Cheol ParkNam Cheol Park More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1987AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Testosterone (T) regulates nitric oxide synthase and is necessary to achieve an optimum response to PDE5 inhibitors for erectile dysfunction. Recently, tadalafil was found to be effective for treating lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). We studied the relative importance of the T level in patients with LUTS and determined whether the T level predicts the response to tadalafil 5 mg once daily for LUTS/BPH. METHODS After a 4-week washout period, 122 men older than 45 years without (n=62, T level ≥300 ng/dl) and with (n=60, T level <300 ng/dl) hypogonadism were given tadalafil 5 mg once daily for 12 weeks. We assessed its impact and the severity of LUTS/BPH using the International Prostate Symptom Score (IPSS) and BPH Impact Index (BII) and IPSS quality-of-life (IPSS-QoL) subscores. Safety was assessed using treatment-emergent adverse events. RESULTS The…
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