The Study of Tadalafil and Tamsulosin as Monotherapy for Lower Urinary Tract
Abstract
Introduction: Benign prostatic hyperplasia (BPH) is highly prevalent in elderly men and often results in lower urinary tract symptoms (LUTS), including urinary frequency, urgency, nocturia, intermittency, straining, incomplete emptying, and a weak urinary stream. LUTS secondary to BPH (LUTS/BPH) increases with age and negatively impacts patients' quality of life. In addition to surgical interventions, the current standard treatments for LUTS/BPH consist of α1-adrenergic blockers, 5α-reductase inhibitors and phytotherapies (used alone or in combination). Although efficacious, these therapies have the potential for side effects related to sexual dysfunction.Materials and Methods: This is a prospective study conducted by Department of Urology, Arupadai Veedu Medical College, Puducherry from January 2020 to December 2020. After obtaining written informed consent, patients were registered and divided into the following two groups randomally by card method: Tamsulosin group (group T), receiving 0.4 mg of tamsulosin hydrochloride once daily in the evening, and tadalafil group (group D), receiving 5 mg of tadalafil in the evening after meal.Results: A total of 120 patients were included in the study. They were compared in terms of age, prostate size, postvoid residual urine, uroflow parameters IPSS and IIEF score. Mean age of patients was comparable 68.4+/-12.3 for tamsulosin group and 67.2+/-11.8 in tadalafil group. Mean prostate size was 56 and 52 respectively. Datas for Prostate…
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