Comparing Effect of Sitagliptin versus Empagliflozin as Add on Therapy to Metformin in Patients with Type 2 Diabetes Mellitus
Abstract
Background: Type 2 Diabetes Mellitus (T2DM) presents a substantial health challenge. Metformin is established as a standard treatment. This study evaluates sitagliptin, a dipeptidyl peptidase-4 inhibitor, and empagliflozin, a sodium-glucose cotransporter-2 inhibitor, as adjunct therapies to improve T2DM management. Objective: To compare effect of sitagliptin versus empagliflozin as add on therapy to metformin in patients with T2DM. Study Design: It was a prospective comparative study. Settings: This study was conducted at the Department of Medicine, DHQ Teaching Hospital, KMU Institute of Medical Sciences, Kohat Pakistan. Duration: 6 months period from March-September, 2023. Methods: A sample size of 100 cases was randomly assigned to either Group A or Group B. In conjunction with the standard metformin regimen (1000 mg twice daily), eligible patients were randomly assigned in a 1:1 ratio to receive either 50 mg of sitagliptin (Group A) or 12.5 mg of empagliflozin (group B) twice daily over 12 weeks. Study visits were scheduled at screening, weeks 0, and 12 of therapy, with no permitted dosage adjustments for the investigational drug. All the data was collected in a predesigned format and data analysis was done using SPSS 27.0. Results: Mean age of the patients in this study was 52.58±10.0 years in which 43.0% (n=43) participants were male while remaining 57% (n=57) were females. Both the groups were comparable with each other and did not possess any inherit difference…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 57 participants or records.
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