Effects of pumpkin on benign prostatic hyperplasia: a systematic review and meta- analysis
Abstract
Introduction: Benign prostatic hyperplasia (BPH) is a common condition affecting aging men worldwide. Pumpkin and its extracts are enriched with antioxidant, anti-androgenic and anti-inflammatory properties.Objectives: To systematically review the effect of pumpkin on the reduction of lower urinary tract symptoms (LUTS) due to bladder outflow obstruction in BPHMethods: The review (PROSPERO ID: CRD42020181395) perused PubMed, EMBASE, Cochrane Library, CINAHL and AGRICOLA databases in two rounds independently by two reviewers according to three screening questions: being a pumpkin related human study, having BPH related outcomes and including quantifiable measurements. Risk of bias assessments were done with GRADE and ROBINS-I Criteria. After assessing the clinical, methodological and statistical heterogeneity, meta-analysis was performed for one outcome with mean difference (MD) using Inverse Variance Method with Review Manager 5.4 software.Results: Out of the 242 articles with de-duplication and screening questions, 10 based on interventional studies among adult males with LUTS were selected in ??third round (8 on pumpkin seeds alone; 2 on pumpkin combined products). International Prostate Symptoms Score (IPSS) was described in nine articles. Other outcomes assessed were quality of life (QOL), prostate volume, Prostate Specific Antigen (PSA), uroflow rate, post-voidal residual volume, frequency of micturition during day and night, nocturia and erectile dysfunction.…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 650 participants or records.
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