The Anterior Fibromuscular Stroma as a Passive Continence Valve: A Testable Hypothesis Linking Aging, Lower Urinary Tract Symptoms, and Tadalafil Response
Abstract
A FOUNDATIONAL OBSERVATIONPatients under general anesthesia do not leak urine-a routine clinical observation that carries profound mechanistic significance.Lapides et al [1] confirmed experimentally that complete neuromuscular blockade does not produce incontinence in subjects with intact lower urinary tracts.The principle is unambiguous: passive urinary continence is independent of active muscular contraction.
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