Utility of pre-transplant bladder cycling for patients with a defunctionalized bladder. A randomized controlled trial
Abstract
OBJECTIVES
To study the necessity of pre-transplant programmed bladder cycling (PBC) in patients with defunctionalized bladder (DB).
METHODS
This RCT included renal transplant (RT) candidates with DB. Eligible patients were assigned to two groups, group I underwent PBC before RT and group II underwent direct RT into the DB. The primary outcome was to assess the efficacy of PBC in improving post- RT bladder capacity. Secondly, to compare its impact on early urological complications and 3-month voiding function and 1-year graft function and survival. Graft function was evaluated using serum creatinine and eGFR using MDRD equation.
RESULTS
Groups I included 23 patients and group II included 20 patients. The mean ±SD of bladder capacity was 88.7±11.7ml and 90.6 ±9.8ml in both groups, respectively (P= 0.5). In group I, PBC increased bladder capacity to 194.7 ±21.2 ml (P<0.001). Targeted bladder capacity was achieved in 19 (82.6 %) patients and two patients developed UTI. At 3-months, bladder capacity, compliance and bladder contractility index improved significantly in both groups with a significant reduction in maximum detrusor pressure with no significant difference between both groups (P= 0.3,0.4, 0.2 and 0.8, respectively). Urinary leakage occurred in one (4.3%) and three patients (15%) in group 1 and 2, respectively (P=0.2). At 1-year, no statistically significant differences in the median (IQR) serum creatinine (P= 0.05) and eGFR (P= 0.07) between both groups were noted.…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 23 participants or records.
Read the paper
Related studies
- Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling
- Drugs Used in “Chemsex”/Sexualized Drug Behaviour—Overview of the Related Clinical Psychopharmacological Issues
- Luteolin Inhibits Dexamethasone‐Induced Osteoporosis by Autophagy Activation Through miR‐125b‐5p/SIRT3/AMPK/mTOR Axis, an In Vitro and In Vivo Study
- Cutting-edge insights into liver fibrosis: advanced therapeutic strategies and future perspectives using engineered mesenchymal stem cell-derived exosomes
- Can we predict and manage persistent storage and voiding LUTS following bladder outflow resistance reduction surgery in men? ICI‐RS 2023
- Chylomicron-mimicking supramolecular nano emulsion for oral luteolin delivery against hyperuricemia
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.