Chromanone Oxime Analogs of Quinolone Drugs as Cytotoxic Agents: In Vitro Cytotoxicity Evaluation and In Silico Study
Abstract
The quinolone drugs such as ciprofloxacin, norfloxacin, and levofloxacin are well-known antibacterial agents with low cytotoxic activity. However, modifying these drugs could improve their cytotoxic activity against cancer cells and switch their potential towards anticancer activity. We describe the chromanone oxime analogs of ciprofloxacin, norfloxacin, and levofloxacin as potential cytotoxic agents. The cytotoxic activity of target compounds (A-F) was evaluated against two cancer cell lines (HepG2, hepatocellular liver carcinoma, and CT26, Murine colon carcinoma) and a normal epithelial cell line, namely CHO (Chinese hamster ovary) by using MTT colorimetric assay. Furthermore, the binding properties of the representative analog (norfloxacin derivative) were investigated by docking study and molecular dynamics simulation.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.