Malignant proliferating trichilemmal tumors arising in patients with multiple trichilemmal cysts: A case series
Abstract
CT: computed tomography MPTT(s): malignant proliferating trichilemmal tumor(s) PET: positron emission tomography PTT(s): proliferating trichilemmal tumor(s) TC(s): trichilemmal cyst(s) INTRODUCTION Proliferating trichilemmal tumors (PTTs) are rare tumors that arise from the outer root sheath of the hair follicle. They typically occur on the scalp of elderly women and commonly correspond to transformation of a simple trichilemmal cyst (TC). PTTs can reach sizes up to 25 cm and are most often benign, but malignant transformation is possible with the presence of local invasion, atypia, and necrosis. Clinically, malignant proliferating trichilemmal tumors (MPTTs) present as rapidly growing exophytic ulcerated tumors. Here, we report 4 cases of MPTTs and multiple TCs in middle-aged men and women with typical and atypical localizations, along with 3 different simultaneous transformation stages in one patient, and concomitant leukonychia in another.
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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