Effects of mixed-technology CO2 and Ga-As laser in patients with hidradenitis suppurativa–A case series
Abstract
AFL: ablative fractional laser HS: hidradenitis suppurativa NAFL: non-ablative fractional laser INTRODUCTION Hidradenitis suppurativa (HS) is a chronic inflammatory condition with a complex pathophysiology, including genetic, environmental, and microbiological factors. One of the early pathogenic changes in the disease’s development is considered to be follicular occlusion in apocrine glandebearing skin. The natural history of HS is characterized by the recurrent development of inflammatory nodules, abscesses, and sinus tracts with subsequent scarring. The disease is associated with significant morbidity and requires long-lasting, continuous care. Over the last 2 decades, various laser treatments have increasingly been used in HS management, primarily ablative CO2 (10,600 nm) with secondary intention healing and Nd:YAG (1064 nm) for selective destruction of the follicular unit. Ablative fractional lasers (AFLs) have also been reported to improve scarring and, in combination with Nd:YAG, reduce inflammation. To our knowledge, no reports on the use of non-ablative fractional lasers (NAFLs Ga-As, 1540 nm) exist to date, although NAFLs have been shown to improve inflammatory acne.
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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