Heart block in patients with coronavirus disease 2019: A case series of 3 patients infected with SARS-CoV-2
Abstract
Introduction In December 2019 a novel coronavirus, SARS-CoV-2, was identified as the pathogen causing coronavirus disease 2019 (COVID-19) in Wuhan, Hubei Province, China. By the end of January 2020, the World Health Organization declared the outbreak of SARS-CoV-2 a Public Health Emergency of International Concern. Respiratory illness remains the main clinical manifestation of COVID-19, but involvement of other systems, including the cardiovascular system, has been well documented. It is estimated that up to 19.7% of patients were noted to have cardiac injury, based on literature from Wuhan, China. Cardiac arrhythmia has been reported in 16.7% of patients, without further specification. Effects on the conduction system have not been reported, besides a few case reports. We present a case series of 3 patients with otherwise normal cardiac structure and function and without prior cardiac history who were admitted to the intensive care unit with COVID-19 and developed periods of complete heart block during their clinical course without any other identifiable etiology. We believe this is a novel effect of COVID-19, and thus it is important for clinicians to be aware of this potential manifestation of disease.
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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