OC19 - Bone turnover markers in arginine vasopressin deficiency: a cross-sectional comparison with primary polydipsia and healthy controls
Abstract
Arginine vasopressin (AVP) and oxytocin (OXT) are neurohypophyseal hormones known to exert opposing effects on bone metabolism. Based on animal models, AVP has been shown to reduce bone formation and promote resorption via AVP V1a receptor signaling, whereas OXT promotes osteoblast differentiation and activity. Despite the well-established cellular actions of these hormones on osteoblasts and osteoclasts in preclinical studies, data from human studies are lacking, particularly regarding bone metabolism in populations with a deficiency of AVP and possibly OXT, such as individuals with AVP deficiency (AVP-D, previously referred to as central diabetes insipidus). This study aimed to evaluate bone turnover markers in patients with AVP-D compared to individuals with primary polydipsia (PP) and healthy controls (HC).
This was a secondary analysis of a prospective trial that included adult HC and patients diagnosed with either PP or AVP-D, all of whom underwent a novel copeptin stimulation test with urea. Laboratory assessments were performed at baseline and included markers for bone resorption (C-terminal telopeptide of type I collagen, CTX) and bone formation (N-terminal propeptide of type I procollagen, P1NP), as well as 25OH vitamin D, serum calcium, and phosphate. Patients on chronic steroid therapy (except budesonide and corticosteroid replacement therapy), those with a history of osteoporotic fractures, or those receiving long-term treatment with antiresorptive agents were…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 47 participants or records.
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