Chondrocyte Columns are Shorter in the Growth Plate of Collagen XXIV Null Mice
Abstract
Collagen XXIV is fibrillar type of collagen that is a component of bone. Because its function is unknown, collagen XXIV knock out (KO) mice were generated, and their long bones were compared to those of age‐matched wild type (WT) mice. MicroCT analysis indicated that the KO mouse femurs were less mineralized. Histology of bone sections showed the growth plate to be smaller in the KO mice. At 5 months of age, the wild type mouse growth plate contained a physis of uniform thickness that stained light blue (amphophilic), and was composed of cartilage with regular columns of chondrocytes perpendicular to the physis. Secondary spongiosa continued from the primary as eosinophilic lamellar bone. However, in the KO mouse growth plate, the columns of chondrocytes were shorter, the cells within the columns appeared to be less organized, and fewer chondrocytes became hypertrophic. These features may correlate with their being unable to develop into osteoblasts. No detectable differences were seen in articular cartilage, cortical bone or the boney trabeculae in the marrow cavities.
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