In Reply to the Letter to the Editor: Involvement of Irisin in Age‐Related Osteoporosis and Its Inhibitory Effect on the Senescent Marker p21 in Osteoblasts
Abstract
We appreciate the thoughtful letter from Professor Naharci regarding our recently published article showing that irisin correlates positively with bone mineral density (BMD) in a cohort of older adult patients and downregulates the senescent marker p21 in osteoblasts. We thank him for the interest in our recent work and welcome the opportunity to respond to his comments. As noted by Naharci, several chronic diseases could have influenced the levels of circulating irisin measured in our cohort of older adult patients. In agreement with this premise, in our study, we enrolled patients by excluding all subjects with at least one chronic disease. Because our primary outcome was to investigate possible links between circulating irisin, FNDC5 expression in skeletal muscle, and BMD, the main exclusion criteria were taking anti-osteoporosis therapy and physical impairments affecting the performance of daily activities. However, subjects were also excluded if they had renal failure with glomerular filtration rate 90 mmHg, systolic blood pressure >140 mmHg, any impairment of glucose metabolism such as diabetes or pre-diabetes, glucocorticoid use within the past 2 years, and thyroid, parathyroid, and liver diseases. Future studies aimed at performing similar investigations on irisin in osteoporosis and muscle atrophy will certainly be relevant, including comparisons between possible comorbidities. However, we considered that this type of investigation was premature in our study because…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 102 participants or records.
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