Osteosarcoma of the mobile spine: a single-institution experience of 32 patients
Abstract
BACKGROUND CONTEXT: Osteosarcoma of the mobile spine is a rare and complex condition, with limited case series informing treatment decisions. Recent advancements in treatment paradigms, particularly in en bloc resection and novel radiation techniques, may incite new treatment guidelines and improve patient outcomes. The clinical outcomes of patients treated for osteosarcoma of the mobile spine at our institution were reported over a decade ago, and this study provides an updated assessment of management strategies and patient outcomes since the initial publication.
PURPOSE: To provide an updated analysis of clinical results for the treatment of mobile spine osteosarcoma.
STUDY DESIGN/SETTING: Retrospective cohort study.
PATIENT SAMPLE: A total of 32 patients treated at a single center for osteosarcoma of the spine over 22 years.
OUTCOME MEASURES: Estimation of overall patient survival, local recurrence, and the presence of metastatic disease.
METHODS: Inclusion criteria were adult patients treated for osteosarcoma originating in the vertebral column with the exclusion of the sacrum at Massachusetts General Hospital between 2001 and 2023. The overall survival was evaluated using the Kaplan-Meier method, grouped by type of resection (en bloc versus intralesional) and histological subtype (osteoblastic, chondroblastic, other/unknown). Prognostic factors were assessed using Cox proportional hazards modeling.
RESULTS: A total of 22 of the 32 patients were given en bloc resection,…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 32 participants or records.
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