The Alteration in Parathyroid Hormone and Calcitonin of Pregnant Women in Babylon Governorate
Abstract
Background The peptide hormones parathyroid hormone (PTH) and calcitonin (CT) both work on osteoblasts (bone-forming cells) and osteo-clasts (bone-resorbing cells) to regulate calcium homeostasis. Aims of the study This study aimed to evaluate the changes in serum levels of parathyroid hormone and calcitonin in pregnant and non-pregnant women in Babylon Governorate, Iraq. Materials and methods This study designs as a case-control study performed on pregnant women who attended Women’s and Children’s Hospital in Hilla and Shomali General Hospital in Babylon Governorate. Forty pregnant women with a range age (18-40 years) and 50 healthy subjects with non-pregnant women with range age (18-40 years) visited the hospital for routine check-ups without any history of chronic diseases, acute illness and infection. The biochemical parameters were determined by the sandwich ELISA technique. Results The results show a significant increase in levels of parathyroid hormone (PTH) and calcitonin (CAL) in pregnant as compared with the non-pregnant group (277.7 ± 47.87 ng/mL),( 72.58 ± 12.76 ng/mL) and (21.89 ± 4.412 ng/mL), ( 9.65 ± 1.921 ng/mL) respectively. The significant difference (p-value < 0.0001). Conclusion In conclusion, the present study finds that pregnant women experience significant hormonal changes in PTH and CT, which indicates the necessity of diagnosing these changes and treating them for the success of this pregnancy.
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 50 participants or records.
Read the paper
Related studies
- Irisin Enhances Osteoblast DifferentiationIn Vitro
- Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo
- Interaction between Schwann Cells and Osteoblasts In Vitro
- Administration of cinnamaldehyde promotes osteogenesis in ovariectomized rats and differentiation of osteoblast in vitro
- The Effect of the Major Components of Fructus Cnidii on Osteoblasts In Vitro
- Estrogen depletion alters osteogenic differentiation and matrix production by osteoblasts in vitro
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.