A cross-sectional comparison of serum bone markers in patients on stable abacavir (ABC) or tenofovir (TDF) containing therapy
Abstract
Methods Prospective, cross-sectional, single-centre study of individuals stable for >6 months on ABCor TDF-based regimens (naive to TDF and ABC respectively) and <50 cps/ ml. The study was designed to measure marker of renal and bone function. The serum bone markers were quantified: alkaline phosphatase (ALP; specific and therefore total ALP are useful markers of bone turnover, specifically resorption), beta crosslaps (measure of type I collagen degradation fragments, a marker of osteoclast activity or bone resorption) and osteocalcin (a polypeptide secreted by osteoblasts, a marker of bone formation). Parameters independently, significantly associated with changes in these markers by univariate analysis (p < 0.15) were entered into a multivariable regression model.
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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