The prognostic and diagnostic value of fibroblast growth factor 23 in patients undergoing hemodialysis
Abstract
Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone secreted by osteoblasts and osteocytes into the systemic circulation. It exerts its effects on the kidneys, parathyroid glands, heart, and bones. FGF23 is a critical phosphaturic hormone that, alongside parathyroid hormone (PTH), regulates phosphate reabsorption and calcitriol (1,25(OH)₂D) synthesis in the kidneys. The present study aimed to evaluate the diagnostic and prognostic significance of fibroblast growth factor 23 in patients undergoing hemodialysis.
Methods. A total of 88 patients were examined in this cross-sectional study. The cohort comprised 36 women (40.9%; 95% CI 30.64–51.18) and 52 men (59.1%; 95% CI 48.82–69.36), with a mean age of 55.81 ± 13.14 years. Group 1 consisted of 69 patients with stage 5 chronic kidney disease (CKD) receiving renal replacement therapy via hemodialysis, while Group 2 included 19 patients with stage 3 CKD.
Results. FGF23 levels were elevated in 67 patients (97.1%; 95% CI 91.87–99.72) in Group 1, with a median (Me) of 1258.32 pg/mL (interquartile range [IQR] 169.46–1338.46). In Group 2, FGF23 levels were elevated in 18 patients (94.7%; 95% CI 80.58–100), with a median of 150.5 pg/mL (IQR 74.22–929.12). A significant difference was observed between the groups (p 0.05), total calcium (r = 0.04; p 0.05). Significant correlations were found between FGF23 and creatinine (r = 0.41; p < 0.005), urea (r = 0.33; p < 0.005), urine volume (r = -0.75; p < 0.005), and hemodialysis…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 88 participants or records.
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