P366 - ECE_3280 - Effect of genetic variability and plasma concentration of osteocalcin and its relationship with serum testosterone levels in men
Abstract
Bone is recognised as an endocrine organ, playing an active role in the regulation of energy metabolism and male reproductive function. Osteocalcin (OC), secreted by osteoblasts, stimulates testicular steroidogenesis through the bone–testis axis via the GPRC6A receptor in the Leydig cells. Despite evidence of this OC actions from animal models, human studies remain scarce. This study aimed to evaluate the association between serum testosterone (T) levels, metabolic and bone parameters, and the genetic variability of osteocalcin (BGLAP, rs1800247) and its receptor (GPRC6A, rs2274911) in men.
A retrospective cross-sectional study was conducted in adult men stratified into four groups according to total serum testosterone: ≤2.5; >2.5–≤3.2; >3.2–<4 and ≥4 ng/mL. Anthropometric, biochemical, hormonal and DXA bone mineral density data (QDR Discovery, Hologic) were collected. Genotyping of rs1800247 and rs2274911 was performed using endpoint genotyping. Statistical analysis included parametric and non-parametric tests, ANOVA, genetic association tests, and Pearson/Spearman correlations, with P < .05 considered significant.
A group of 123 men, with a mean age of 57.2 years, a median weight ranging from 79.1 to 91.3 kg, and a mean height of 1.7, was studied. Statistically significant differences were observed between testosterone groups for several key parameters. The group with T ≥4 ng/mL presented higher levels of vitamin D (P = .026), bone alkaline phosphatase (P = .027), SHBG (P…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 123 participants or records.
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