Serum Osteocalcin Is an Important Predictor of Central and Total Adiposity and Insulin Resistance
Abstract
Abstract Objectives Osteocalcin (OC) is a non-collagenous protein expressed by osteoblasts and has gained immense attention due to its endocrine role in modulating glucose homeostasis and fat mass. However, the relationship of this bone turnover marker with adipose tissue distribution and alternative methods of insulin resistance (IR) risk evaluation have not been fully explored. Considering that a better understanding of OC hormone role may be a possible pathway to improve cardiometabolic health, the objective of this study was to investigate the association of OC with central and total adiposity and IR risk. Methods This is a cross-sectional study with 154 non-osteoporotic men (57.1%) and women (42.9%), mean age and BMI were 37.3 ± 13.1 years and 29.1 ± 5.5 kg/m², respectively. Weight, height and waist circumference (WC) were measured to calculate BMI and waist-height ratio (WhR). Body composition was assessed by dual energy x-ray absorptiometry (DXA). Blood samples were obtained to analyze serum OC, fasting glucose, insulin, adiponectin, and triglycerides. IR was evaluated using traditional (Homeostatic Model Assessment for Insulin Resistance, HOMA-IR) and alternatives methods (HOMA-adiponectin, HOMA-AD; triglyceride-glucose (TyG) index; quantitative insulin-sensitivity check index, QUICKI). Multivariable linear regression models were performed to determine the association between OC and outcomes. Results The sample mean OC concentration was 20.7 ± 17.1 ng/mL. After…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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