The effect of regular fitness training, sex hormones, and turnover of selected bone markers on sclerostin levels in young women
Abstract
Introduction Regular physical activity (PA) is a recognized factor stimulating bone formation. In recent years, osteocytes have been shown to be involved in the metabolism of bone tissue in addition to osteoblasts and osteoclasts. The aim of the study was to analyze the effects of regular fitness training, sex hormones, and selected bone turnover markers on sclerostin levels in young women. Material and methods The cross-sectional study involved 78 women including 39 who regularly engaged in fitness training (for 1 h three times a week for 3 months) and 39 leading a sedentary lifestyle. Anthropometric measurements and glucose, lipids, insulin, estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate, intact parathyroid hormone (iPTH), vitamin D, osteocalcin, β isomer of C-terminal telopeptide of type I collagen (β-CTx) and sclerostin levels were measured. Results Activity of women (study group) who were on a high level of PA ranged between 2262 and 6606 MET/min/week (mean, 3843.16; SD = 1230). All of the control group were on low level of PA (198-1617 MET/min/week; mean, 841.06; SD = 302.01). Significantly higher levels of iPTH and β-CTx were observed in the study than in the control group (p 0.12), osteocalcin (p > 0.23), or sclerostin levels (p > 0.37) between groups. There were significant negative correlations between log10 sclerostin and log10 DHEA levels (r = –0.24; p < 0.05). A multivariate stepwise…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 78 participants or records.
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