Serum Osteocalcin Is Inversely Associated With Adipocyte-Specific Fatty Acid–Binding Protein in the Korean Metabolic Syndrome Research Initiatives
Abstract
Recent studies (1) have reported that adipokines might act in a paracrine manner on osteoblasts and suppress osteoblast activity or differentiation—or both—in pathological conditions. Adipocyte-specific fatty acid–binding protein (A-FABP) is highly expressed in adipose tissue and may act systemically to regulate lipid and glucose metabolism (2). However, the association between serum osteocalcin with adipokines and A-FABP remains unclear in humans. Therefore, the aim of this study was to clarify the relationship between serum osteocalcin and the parameters of the metabolic syndrome and the association of serum osteocalcin with adipokines and A-FABP.
This was a cross-sectional study carried out by the Korean Metabolic Syndrome Research Initiative. The 124 obese subjects underwent a standardized examination at four university hospitals in Korea. The control …
How strong is the evidence?
Evidence Hub reads this as a cross-sectional. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 124 participants or records.
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