Secondary Choroidal Osteoma in the Setting of Uveal Pathology: 4 Case Reports and Review
Abstract
Introduction: Choroidal osteoma is a rare benign tumor where mature bone replaces the choroid. Possible causes include inflammation, trauma, hormones, disorders of calcium metabolism, environmental factors, genetics, or osseous choristoma. This paper discusses 4 cases and literature regarding choroidal osteoma occurring concurrently with or secondary to uveal pathologies including uveitis and pachychoroid spectrum.
Case presentations: In case 1, a 41-year-old man with central serous chorioretinopathy (CSCR) in both eyes (OU) developed a choroidal osteoma in the left eye (OS) 8 years after the initial visit. Type 1 macular neovascularization (MNV) developed 4 years later at age 53. In case 2, a 50-year-old woman with CSCR OU developed a choroidal osteoma OS 15 years after the initial visit. The lesion gradually enlarged over another 15 years of observation. In case 3, a 24-year-old woman with Vogt-Koyanagi-Harada disease treated with systemic corticosteroids for 6 months developed choroidal osteoma OU and type 2 MNV in the right eye (OD) 16 years after the initial visit. In case 4, a 55-year-old man with concurrent posterior scleritis and choroidal osteoma OS developed type 1 MNV 13 years after the initial visit. He had a history of unknown uveitis treated with high-dose corticosteroid therapy 21 years previously. In all 5 eyes, the presence of osseous tissue in the choriocapillaris and Sattler's layer was confirmed by optical coherence tomography, B-mode ultrasound, or…
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