Microscopical analysis of explanted Titanium alloy customised meshes for bone augmentation: a case series study
Abstract
The use of dental implants is a very common procedure [1]. For ideal prosthetic design, implants must be inserted in a correct 3D position [2]. Patients may present alveolar ridge defects as a consequence of periodontal disease, dental trauma, traumatic extraction, or genetic anomalies, which do not allow the correct implant position [3, 4]. Different treatment options have been described to reconstruct these defects, which may include inlay and onlay block bone grafts, crestal splitting, osteogenetic distraction, and guided bone regeneration (GBR) using resorbable and non-resorbable barrier membranes [5]. Of these, GBR seems to be the most reliable and predictable, providing excellent long-term stability The basic principle of GBR involves placing a mechanical barrier to protect the blood clot and to isolate the bony defect from the surrounding connective and epithelial tissue invasion. This space is needed to allow the osteoblasts to access the space intended for bone regeneration. Titanium meshes, as an alternative to membranes, have been used for a long time as a predictable technique for bone regeneration and, owing to their rigidity, the adaptation onto the defect and maintenance of their shape can be more stable. To overcome the main drawbacks, which are the remaining sharp margins after cutting and the increased surgical time required for their shaping and fitting, pre-shaping of the mesh on a stereolithographic model (STL) of the patient’s jaw can be an alternative…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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