Potential effects of exercise on bone biopsy findings in patients receiving hemodialysis: a review of our case series
Abstract
Although no large studies have shown that exercise helps maintain bone volume in the two representative types of renal osteodystrophy (ROD), some case reports have supported this effect, leading to speculation about the usefulness of exercise in these conditions. Dialysis patients can develop chronic kidney disease–mineral and bone disorder, which includes bone lesions termed ROD. Examples of ROD lesions are osteitis fibrosa (high-turnover bone) due to secondary hyperparathyroidism, which is associated with high parathyroid hormone (PTH) levels, and adynamic bone (low-turnover bone) due to hypoparathyroidism, which is associated with low PTH levels. In osteitis fibrosa, osteoblastic bone formation and osteoclastic bone resorption occur simultaneously in different locations, double tetracycline (Tc) labeling is observed, and a woven bone structure is characteristic. Moderate exercise promotes bone formation and maintains bone mass and volume and connectivity of cancellous bone. However, if patients do not exercise enough, bone resorption becomes dominant, the cancellous bone becomes osteopenic and is replaced by fatty marrow, the dense cortical bone becomes more porous, osteocyte nuclei are lost, and empty lacunae develop. In adynamic bone, tests show no evidence of active osteogenesis by osteoblasts, no bone resorption by osteoclasts, and no Tc labeling, but studies have shown that exercise may help maintain bone mass by minimodeling and improving lamellar bone structure.…
Read the paper
Related studies
- Irisin Enhances Osteoblast DifferentiationIn Vitro
- Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo
- Interaction between Schwann Cells and Osteoblasts In Vitro
- Administration of cinnamaldehyde promotes osteogenesis in ovariectomized rats and differentiation of osteoblast in vitro
- The Effect of the Major Components of Fructus Cnidii on Osteoblasts In Vitro
- Estrogen depletion alters osteogenic differentiation and matrix production by osteoblasts in vitro
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.