Fine structure of ossification in craniopharyngiomas
Abstract
Three cases of adamantinomatous craniopharyngiomas were examined by light and electron microscopy and special attention was paid to the formation of ossified tissue. The tumors were composed of neoplastic epithelial cells with keratinized cell nests and fibrous connective tissue. Keratinized cell masses sometimes directly contacted fibrous connective tissue. In these border areas, multipotential mesenchymal cells in the latter may have differentiated into osteoblasts. Ultrastructurally, these osteoblastic mesenchymal cells were surrounded by amorphous ground matrix and collagen fibrils. Membrane-bound vesicles were occasionally seen among the spaces between the collagen fibrils. These vesicles were presumably derived from osteoblastic mesenchymal cells and were morphologically similar to matrix vesicles. Precipitation of hydroxyapatite crystals in these vesicles was considered to be the initial stage of ossification. Further mineralization of adjacent collagen fibrils resulted in the formation of small bone trabeculae. Then apositional growth of ossified tissue occurred in the surrounding keratinized cell masses.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Irisin Enhances Osteoblast DifferentiationIn Vitro
- Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo
- Interaction between Schwann Cells and Osteoblasts In Vitro
- Administration of cinnamaldehyde promotes osteogenesis in ovariectomized rats and differentiation of osteoblast in vitro
- The Effect of the Major Components of Fructus Cnidii on Osteoblasts In Vitro
- Estrogen depletion alters osteogenic differentiation and matrix production by osteoblasts in vitro
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.