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Intramedullary osteoblastoma of the femur: a case report

Thompson B, Gibson J, Uldin H, Vaiyapuri S, Botchu R

Skeletal radiology, 2026

Abstract

Introduction: Osteoblastoma is a rare primary bone tumour, and the lesions are typically intracortical affecting long-bone metaphysis and the posterior spine. The histological hallmark is characteristic networks of trabeculated woven bone, usually lined by osteoblasts within a vascularised stroma. This case report details an unusual case of an intramedullary osteoblastoma of the femur.

Case presentation: A 22-year-old male presented with an eight-month history of right knee pain on a background of a previous distal tibia non-ossifying fibroma. The patient underwent cross-sectional imaging, and a biopsy was obtained confirming a lesion in the distal femoral diametaphysis. MRI showed multiple internal fluid levels and septations with a sclerotic rim and associated marrow oedema, cortical sclerosis, and periosteal soft tissue oedema. Subsequent biopsy provided histological confirmation of osteoblastoma.

Conclusion: This case is presented to highlight the rare anatomical location for osteoblastoma: in the medullary canal of the distal femur.

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