Iron and Bone Pathophysiology
Abstract
Clinical and preclinical studies indicate that unbalanced systemic iron concentrations negatively affect bone health. Despite distinct underlying mechanisms, both iron deficiency and iron overload result in decreased bone mineral density and an increased fracture risk, the latter being associated with higher morbidity and mortality rates. In iron deficiency, both osteoclasts and osteoblasts suffer from the lack of iron to efficiently execute metabolic processes and produce enough energy for bone resorption and formation, respectively. In contrast, iron overload inhibits osteoblast differentiation and function by increasing the production of reactive oxygen species and lipid peroxidation, while it stimulates osteoclastogenesis and bone resorption. Besides the direct effects of iron on bone, regulators of systemic iron homeostasis have also been shown to impact bone homeostasis. This chapter summarizes current knowledge on the regulation of bone cell function and bone homeostasis by iron. Furthermore, it discusses new avenues for the treatment of iron-related bone loss.
Read the paper
Related studies
- Benign periarticular, bone and joint lipomatous lesions
- A review of the physiological and histological effects of laser osteotomy
- Quality of bone healing: perspectives and assessment techniques
- Effects of bioactive lipids and lipoproteins on bone
- Bone structure and function
- Quantifying bone structure, micro-architecture, and pathophysiology with MRI.
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.