Circulatory pathology in osteoarthritic subchondral bone
Abstract
Objective: With the recognition that crosstalk between articular cartilage and subchondral bone may contribute to osteoarthritis (OA), interest in the subchondral osteoblast secretome has grown significantly. Osteoblasts respond to alterations in their microenvironment by expressing a range of signaling and structural cytokines affecting bone remodeling and cartilage breakdown characteristic of OA. This narrative review explores observations made with circulatory imaging of subchondral bone in OA and presents a reconciliation of them in the context of a subchondral hypoxic microenvironment and osteoblast synthetic responses. The pathogenesis of OA is multifactorial and venous stasis, the resulting intraosseous microenvironment, and the consequent osteoblast responses appear to play significant roles.
Design: This is a narrative review. A literature search was conducted in PubMed (Medline), Google Scholar, and the Cochrane Library. Search criteria included OA associated with vascularity or perfusion status, osteoblast secretome and cytokines, and hypoxia.
Results: Bone is a highly vascular tissue, and its circulatory integrity is a major determinant of the osteoblast microenvironment and secretome. Static imaging studies have shown an altered venous pattern in human OA compared to normal hips with slower elimination of contrast agent consistent with venous stasis. Intraosseous hypertension and hypoxia have also been observed in OA compared to normal subchondral bone.…
Read the paper
Related studies
- Irisin Enhances Osteoblast DifferentiationIn Vitro
- Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo
- Interaction between Schwann Cells and Osteoblasts In Vitro
- Administration of cinnamaldehyde promotes osteogenesis in ovariectomized rats and differentiation of osteoblast in vitro
- The Effect of the Major Components of Fructus Cnidii on Osteoblasts In Vitro
- Estrogen depletion alters osteogenic differentiation and matrix production by osteoblasts in vitro
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.