C-type lectin receptors: bone remodeling and therapeutic potential
Abstract
Osteoimmunology explores the interplay between the skeletal system and the immune system. It focuses on the identification of shared signaling pathways and the mechanisms of mutual regulation. Bone homeostasis depends on the balance between the activity of bone-forming osteoblasts and bone-resorbing osteoclasts. Interestingly, the crosstalk between osteoclasts, osteoblasts, osteocytes, and immune cells not only shapes bone remodeling but also influences immune responses. A central pathway in osteoclast differentiation is the receptor activator of nuclear factor-κB ligand (RANKL) signaling, which induces NFATc1, the master transcription factor of osteoclastogenesis. Recent evidence shows that immunoreceptor tyrosine-based activation motif (ITAM)-containing co-receptors enhance RANKL-induced signaling, underscoring their essential role in osteoclast activation and differentiation. Increasing attention has been directed toward C-type lectin receptors (CLRs), such as Dectin-1, Mincle, and DC-SIGN. These receptors have historically been recognized for their functions in antifungal and antibacterial immunity. However, their expression on both immune cells and osteoclasts links CLR signaling to osteoclastogenesis, as CLR engagement signals through ITAM pathways, contributing to NFAT activation. Therefore, CLRs could function as co-receptors for RANKL in human osteoclast biology, although the underlying mechanisms remain poorly defined. This review synthesizes current knowledge on…
Read the paper
Related studies
- Irisin Enhances Osteoblast DifferentiationIn Vitro
- Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo
- Interaction between Schwann Cells and Osteoblasts In Vitro
- Administration of cinnamaldehyde promotes osteogenesis in ovariectomized rats and differentiation of osteoblast in vitro
- The Effect of the Major Components of Fructus Cnidii on Osteoblasts In Vitro
- Estrogen depletion alters osteogenic differentiation and matrix production by osteoblasts in vitro
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.