Influence Of Surface Topography On Osteoblast Cell Adhesion On Polymeric Biomaterials: A Systematic Review
Abstract
Background: Surface topography is known to affect osteoblastic adhesion; however, consolidated evidence regarding how polymeric surface topography affects adhesion is lacking in the literature. Aims: To identify studies that investigate the effect of polymeric biomaterials’ surface topography on osteoblast adhesion so that a descriptive summary of topographical features that enhance or impede osteoblast adhesion may be inferred. Methods: Studies describing osteoblasts’ adhesion to the surface topography of polymeric biomaterials were collected from PubMed, Scopus, ProQuest, EBSCO, EuropePMC, and IEEE Xplore. Studies describing other materials such as metals, ceramics or composites were excluded. Electrospun materials, nonfouling structures, nanoparticle-based materials and studies not describing cell adhesion were excluded. The review followed PRISMA 2020 guidelines. Results: The search resulted in 27 articles for final inclusion in the review. Polymers described were PLLA, PCL, PLGA, Polystyrene and PMMA. Nano and microscale modifications were analysed in these studies, where nanoscale modification affected the cell adhesion number, while microscale modifications affected the cell shape and alignment. Conclusion: Nanotopography (10–100 nm) with moderate microscale roughness (0.1 to 10 microns) may be the recommended topography for cell adhesion, based on studies included.
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Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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