Effectiveness of Marine Bioactive Compound Fucoidan in Stimulating Osteoblast Cells Formation: A Systematic Review
Abstract
BACKGROUND: Bone loss in the oral cavity can occur in various situations, including periodontitis-related issues and complications after tooth extraction. A damaged or lost alveolar bone can be restored through a tissue engineering approach. Fucoidan, a marine biopolymer derived from brown algae, is one biomaterial that aids bone regeneration since it contains biomaterials that can generate new osteoblast cells. AIM: The purpose of this review is to determine whether fucoidan can be employed to promote osteoblast cell growth during bone repair. METHODS: The search strategy was performed in PubMed; Elsevier (Scopus); ScienceDirect; Libgen, and Google Scholar. In addition, a manual hand searching was performed to locate and identify additional studies. RESULTS: Based on the reviewed articles, it has been discovered that five met the inclusion criteria and found that the marine bioactive compound fucoidan can significantly increase the expression of ALP activity. CONCLUSION: Fucoidan is considered to have biological properties, including antithrombotic, anticoagulant, and antioxidant. It also serves as a phenotypic marker during the early stages of osteoblastic differentiation.
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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