Major aspects of mesenchymal stem cell signaling and differentiation into osteoblasts in the optimization of bone formation for dental implant: a systematic review
Abstract
Introduction: In recent decades, the number of dental implant procedures has shown significant growth worldwide, reaching about one million dental implants per year. In Brazil, in recent decades, there has been a very rapid evolution in implant dentistry with high success rates. Several materials can be used as a bone graft, each with different properties, for example, regarding neovascularization. Guided bone regeneration favors the formation of new bone tissue. When grafting procedures are required, the focus is often on the type of biomaterial to be used and the success and predictability of the results. Objective: It was to carry out a concise systematic review of bone regeneration processes using biomaterials and the main molecular and cellular constituents for implant dentistry. Methods: The survey was carried out from January to February 2023 in the Scopus, PubMed, Science Direct, and Scielo databases, using older scientific articles with a gold standard reference up to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias by the Cochrane instrument. Results and Conclusion: It was founded on 128 studies that underwent eligibility analysis. The final sample had 34 eligible studies that were described in the systematic review. Most studies showed homogeneity in their results, with X2=89.8.8% <50%. Due to bone regeneration and biological barriers in graft surgeries, there has been a technological growth of these materials as they point…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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