Expression and Significance of BMP-2 in Osteoblasts from Scoliosis Patients with Neurofibromatosis Type1
Abstract
Introduction: Decreased bone mineral density (BMD) among scoliosis patients with neurofibromatosis type1 (NF1) has been reported. Our previous study showed high proliferation rate but lower differentiation activity of the osteoblasts from scoliosis with NF1. Bone morphogenetic protein-2 (BMP-2) is one of the central regulators of osteoblast differentiation. Whether BMP-2 was involved in the pathogenesis of low BMD and low differentiation activity of osteoblasts in scoliosis with NF1 has not been reported.
Read the paper
Related studies
- Irisin Enhances Osteoblast DifferentiationIn Vitro
- Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo
- Interaction between Schwann Cells and Osteoblasts In Vitro
- Administration of cinnamaldehyde promotes osteogenesis in ovariectomized rats and differentiation of osteoblast in vitro
- The Effect of the Major Components of Fructus Cnidii on Osteoblasts In Vitro
- Estrogen depletion alters osteogenic differentiation and matrix production by osteoblasts in vitro
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.