Effects of Collagen Peptides Derived from Perch Scale Hydrolysates on the Physiological Activity of Osteoblasts
Abstract
A plethora of studies have demonstrated the bioactive properties of collagen peptides, including the promotion of wound healing and bone health. Research has demonstrated that these effects are attributable to their elevated biocompatibility and signaling capabilities. The present study investigated the effects of collagen peptides produced by enzymatic hydrolysis of perch scales on the induction of extracellular matrix formation and osteogenesis. The findings demonstrated that a combination of pre-heating and enzymatic hydrolysis resulted in the optimal peptide yield, with 94.9% of the peptides exhibiting a molecular weight below 1200 Daltons and containing elevated levels of hydroxyproline. The addition of perch scale collagen peptides to fibroblasts 890510-01F ATIT has been demonstrated to effectively induce the production of type I procollagen and fibronectin, a protein associated with the osteoblast phenotype and osteoblast differentiation. It is also worthy of note that experiments conducted using MC3T3-E1 osteoblasts indicate that collagen peptides significantly increased alkaline phosphatase activity by a factor of 1.46. This study demonstrates that collagen peptides derived from perch scales are enriched in bioactive peptides containing C-terminal tyrosine residues, including DYPRNHY and DPYNRHY. These findings provide a scientific basis for the future development of perch scale-derived collagen peptides as dietary supplements or functional food ingredients for…
Read the paper
Related studies
- Irisin Enhances Osteoblast DifferentiationIn Vitro
- Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo
- Interaction between Schwann Cells and Osteoblasts In Vitro
- Administration of cinnamaldehyde promotes osteogenesis in ovariectomized rats and differentiation of osteoblast in vitro
- The Effect of the Major Components of Fructus Cnidii on Osteoblasts In Vitro
- Estrogen depletion alters osteogenic differentiation and matrix production by osteoblasts in vitro
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.