The effect of silicon, silica and silicates on the osteoblast in vitro
Abstract
Silica is an essential trace element in human nutrition and dietary deficiency leads to abnormal bone formation in experimental animal studies (Carlisle, 1972, Schwartz 1972). Silica-containing glasses and glass ceramics, within a certain range, are bioactive, forming a strong bond with bone and soft tissue when they are used as bone replacement materials. The aim of this work was to investigate the effect of silica on the osteoblast in vitro with a view to its eventual incorporation into biomaterials to improve bone-bonding properties.\nTwo distinct approaches were used. The first involved the analysis of silica as a nutrient, by supplementing osteoblast growth medium with sodium metasilicate, and evaluating the osteoblast response in terms of cell growth, mineralisation and cytotoxicity. The second approach examined the response of osteoblasts to silica as a biomaterial. A silica gel was used to isolate the effects of silica on the osteoblast in vitro without the effects of the other ions present in bioactive glass. The biocompatibility of patterned silicon wafers was investigated to evaluate the potential use of these materials in the field of biomaterials. Finally, the bioactivity and osteoblast response to a novel silicon/polymer composites as assesseda s a potential biomaterial.\nThe results of nutrition studies showed that in some cases low levels (1-100ppm) of silicate appeared to have a beneficial effect on bone formation in terms of nodule formation and…
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Evidence Hub reads this as a thesis, done in cell cultures (in vitro), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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