Experimental Study of the Effect of Novel Bioceramics on Osteoblasts in Vitro
Abstract
Objective: To evaluate the cell compatibility of ZrO 2-CBC by studying the effect of ZrO 2-CBC on the proliferation and differentiation of fetal rats' osteoblasts in vitro. Methods: Cell counting, measurement of ALP activity and flow cytometry were used to estimate the effect of ZrO 2-CBC on proliferation and differentiation of osteoblasts by coculturing cells with ZrO 2-CBC for 15?days. Results: It was found that ZrO 2-CBC had no inhibitory effect on osteoblasts at the early phase (P0.05), but it would restrain the proliferation and ALP secretions of osteoblasts at the later phase (P0.05) compared to blank control group. Conclusion: ZrO 2-CBC is a kind of promising dental implant material.
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