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Factitious increases in serum testosterone concentrations related to phenylbutazone therapy

Uzzan B, Dumont-Fischer D, Lahlou N, Bihan H, Boissier MC, Alvarez JC, Perret GY, Cohen R

Fundamental & clinical pharmacology, 2008

Abstract

We report 6 additional observations of a drug/hormone assay interaction between serum testosterone and phenylbutazone intake. This interaction had been described previously only once. We discuss its potential mechanisms, based upon our experimental findings, and its clinical implications.

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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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