Free testosterone and abortion in early pregnancy

Takeuchi T, Nishii O, Okamura T, Yaginuma T, Kawana T

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1993

60 participants

Abstract

OBJECTIVES: To investigate the relationship between percentage of free testosterone (% free T) and the abortion rate in early pregnancy.

METHODS: Progesterone (P), estradiol (E2), total T, sex hormone binding globulin (SHBG), and % free T were measured in sera obtained from 60 pregnant women with normal pregnancy (n = 38) and missed abortion (n = 22) at between 4 and 12 weeks' gestation.

RESULTS: P, E2, total T, and SHBG in 22 patients with missed abortion were significantly lower than those in normal group, whereas % free T was significantly higher. There was a significant negative correlation between % free T and SHBG concentration in the normal group, but not in the missed abortion group. All the subjects in whom % free T was 1.30% and higher subsequently miscarried, but no subject with % free T less than 0.70% had a miscarriage.

CONCLUSIONS: The lower the % free T, the lower the rate of subsequent abortion. The value of % free T may be able to predict pregnancy outcome in early pregnancy.

How strong is the evidence?

Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 60 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

Read the paper

• DOI
• PubMed
• Publisher page

Related studies

• Induced osteoblast differentiation by amide derivatives of stilbene: The possible osteogenic agents Bioorganic & medicinal chemistry letters, 2020
• On model selections for repeated measurement data in clinical studies Statistics in medicine, 2015
• Regulation of GLUT transporters by flavonoids in androgen-sensitive and -insensitive prostate cancer cells Endocrinology, 2014
• Region-specific microRNA signatures in the human epididymis Asian journal of andrology, 2018
• Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety Bioorganic & medicinal chemistry, 2019
• In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor Journal of hazardous materials, 2022

Go deeper in Evidence Hub

Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.

Open this study Sign up free