Testosterone therapy in Klinefelter's syndrome (a prolonged observation)
Abstract
Clinical observations and pituitary gonadal hormone data was gathered in six patients with Klinefelter's Syndrome during a prolonged period of time. The secondary sex characteristics increased and the gynecomastia generally disappeared. Personality changes were also noted. In half of the patients, the abnormal level of luteinizing and follicular stimulating hormone remained elevated. An enlarged sella turcica was discovered in one patient. It is concluded that testosterone therapy is beneficial in all patients with Klinefelter's Syndrome.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
Read the paper
Related studies
- Induced osteoblast differentiation by amide derivatives of stilbene: The possible osteogenic agents
- On model selections for repeated measurement data in clinical studies
- Regulation of GLUT transporters by flavonoids in androgen-sensitive and -insensitive prostate cancer cells
- Region-specific microRNA signatures in the human epididymis
- Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety
- In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.