Association of geriatric nutritional risk index with total testosterone in elderly adults in the US: evidence from NHANES 2011-2016
Abstract
BACKGROUND AND OBJECTIVES: There is growing evidence that deficiencies in specific nutrients can impact testosterone levels in older men. However, research examining the predictive value of overall nutritional status on testosterone levels remains limited. The Geriatric Nutritional Risk Index (GNRI) is an effective tool for assessing the nutritional status of the elderly. Therefore, this study aimed to investigate the potential correlation between the GNRI and serum total testosterone (TT).
METHODS: A representative sample of U.S. males aged 60 years and older who participated in the National Health and Nutrition Examination Survey (NHANES) cycles from 2011 to 2016 was utilized for this cross-sectional study. The research included a total of 829 older adults. Tandem mass spectrometry and liquid chromatography were employed to quantify TT. To examine the association between GNRI and TT, restricted cubic splines (RCS) and weighted multivariate regression analyses were conducted. Subgroup analysis was performed to identify the variables influencing the positive association between GNRI and TT. Additionally, a sensitivity analysis was carried out to compare the weighted and unweighted data.
RESULTS: After adjusting for all other factors, a positive association was found between GNRI and TT. The beta coefficient was 5.59, with a 95% confidence interval of 2.16 to 9.01, and a p-value of 0.003. Compared to the lowest quartile of GNRI (Q1), the second quartile (Q2), third quartile…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 829 participants or records.
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