Urethral reconstruction using amniotic membrane allograft in hereditary androgen insensitivity syndrome: a case series

Mansour M, Raya M, Jrdy AA, Sires AM, Wardeh JA, Alsbekhan AB, Faour S, Kanas M et al.

Journal of surgical case reports, 2023

Abstract

Partial androgen insensitivity syndrome is a rare X-linked disorder. While most cases are sporadic, familial cases are less frequent. The management of this syndrome follows a multidisciplinary approach involving hormone substitution, psychological counseling, and surgical procedures. We present a case series of three young siblings with familial partial androgen insensitivity syndrome who presented with a female phenotype. All of them were managed with hormonal treatment for 6 months followed by surgical reconstruction. The operative procedure involved phalloplasty and urethroplasty using amniotic membrane transplant, which is considered a novel technique in this group of patients. No intraoperative or postoperative complications were observed and good results were achieved within 2 years of follow-up.

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