Ovarian stimulation and retrieval outcomes in transgender males maintained on testosterone: a case series
Abstract
PURPOSE: This study aimed to report on three cases of transgender men who continued testosterone therapy throughout controlled ovarian hyperstimulation for fertility preservation.
METHODS: This was a retrospective case series of three transgender men who presented for oocyte cryopreservation at a university-affiliated fertility clinic and continued gender-affirming testosterone therapy up until or during the controlled ovarian hyperstimulation protocol. The primary outcomes were the number of oocytes retrieved, the number of mature oocytes retrieved, and the total gonadotrophin dose required during stimulation.
RESULTS: The average age of patients in this series was 29.5 years, with an average BMI of 31 kg/m2. Mean serum testosterone prior to starting stimulation was 359 ng/dL. The average AMH and AFC levels were 1.2 ng/ml and 12 follicles, respectively, and the mean number of mature oocytes vitrified was 16. One patient fertilized seven mature oocytes and has an ongoing pregnancy following a single blastocyst embryo transfer.
CONCLUSIONS: This is the largest case series of patients who continued testosterone during ovarian stimulation, with the widest range of testosterone dosing reported, and the first report of a self-carried pregnancy after COS on testosterone. While there is no long-term data as yet, these early findings are reassuring for patients and indicate that proceeding with a stimulation cycle without a testosterone washout period, or continuing testosterone…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Induced osteoblast differentiation by amide derivatives of stilbene: The possible osteogenic agents
- On model selections for repeated measurement data in clinical studies
- Regulation of GLUT transporters by flavonoids in androgen-sensitive and -insensitive prostate cancer cells
- Region-specific microRNA signatures in the human epididymis
- Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety
- In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.