Paternity in idiopathic hypothalamic hypogonadism during testosterone therapy in two unrelated patients
Abstract
When fertility is desired, idiopathic hypothalamic hypogonadism is amenable to treatment with pulsatile low dosage GnRH administration or injections of gonadotrophins. Patients with this disorder are hypogonadal and require therapy with androgens or oestrogens/progestagens. This would presumably lower pituitary gonadotrophin production even further. However, fertility occurring spontaneously during testosterone substitution, as proven by paternity testing, has been described twice. The present report adds two more cases. It is unwise to make a definite statement about infertility in male patients with this condition.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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