Androgen therapy in midlife and older women: a position statement of the Latin American Association of Gynecological Endocrinology (ALEG)
Abstract
OBJECTIVE: Androgens have been prescribed to alleviate symptoms in midlife women, but evidence regarding benefits and risks remains limited, with no clearly established indications for Testosterone therapy. In many Latin American countries, Testosterone is prescribed without specific guidelines, making it difficult to identify patients who might benefit. This position statement aims to summarize evidence and provide a Latin American perspective on androgen therapy in midlife and older women.
METHOD: Data were collected from Cochrane reviews, placebo-controlled studies, meta-analyses, international guidelines, consensus statements, and government regulations published between 2000 and the present. Analyses focused on efficacy, safety, and clinical recommendations for androgen therapy in midlife and older women.
RESULTS: Testosterone therapy for postmenopausal women should be limited to those with hypoactive sexual desire disorder (HSDD) confirmed through a formal biopsychosocial evaluation (Grade A: High). Routine serum measurements of Testosterone or other androgens are not recommended for diagnosis (Grade A: High), but baseline levels should be checked before therapy to exclude elevated concentrations (Grade C: Low). Treatment monitoring should occur within 3-6 weeks, maintaining Testosterone within the premenopausal physiological range (Grade C: Low). Transdermal formulations are preferred. Subcutaneous pellets and compounded "bioidentical" Testosterone are not recommended…
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