Testosterone self-administration in female hamsters
Abstract
Abuse of anabolic-androgenic steroids (AAS) is a growing public health concern. In addition to their anabolic effects, steroids are also reinforcing as demonstrated by testosterone self-administration in male hamsters. However, steroid use in women lags behind that in men. Are androgens also rewarding in females? We determined if female hamsters voluntarily consume testosterone by intracerebroventricular (i.c.v.) self-administration in an operant chamber. Twelve ovary-intact female hamsters self-administering testosterone (1.0 microg/microl) i.c.v. for 19.1 +/- 2.3 days developed a significant preference (P < 0.05) for the active nose-poke (31.5 +/- 6.1 nose-pokes/4 h) over the inactive nose-poke (12.5 +/- 1.1 nose-pokes/4 h). Operant behavior in females was similar to that reported previously for male hamsters. Estrous cycles became irregular 9.6 +/- 2.3 days after the start of self-administration. Regular cycles resumed 13.7 +/- 2.6 days after testosterone was discontinued. To determine the effect of ovarian steroids on androgen self-administration, females were ovariectomized (OVX) and allowed to self-administer testosterone for 10.8 +/- 0.5 days. Afterwards, estrogen was replaced, and self-administration continued for an additional 9.7 +/- 0.6 days. OVX females maintained their preference for the active (23.9 +/- 7.0 nose-pokes/4 h) over the inactive nose-poke (12.6 +/- 3.4 nose-pokes/4 h, P < 0.05), and estrogen had no effect on responding for androgen (active: 25.8 +/-…
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