Autoregulation of testosterone secretion in perfused rat testes
Abstract
Infusion of testosterone into the testicular artery, at concentrations comparable to those that occur in the testicular vein in situ, inhibited LH-stimulated testosterone secretion by rat testes perfused in vitro. This inhibition was rapid and dose responsive. In contrast to testosterone, intra-arterial infusion of 5 alpha-androstan-3 alpha, 17 beta-diol, corticosterone and androstenedione failed to inhibit testosterone secretion. The inhibition of testosterone secretion by intra-arterial infusion of testosterone was reversed by either cessation of testosterone infusion or the simultaneous addition of androstenedione to the artificial perfusion medium. Taken together, these results showed that LH-stimulated testosterone secretion by in vitro perfused rat testes was inhibited by a short-loop negative feedback of testosterone.
Read the paper
Related studies
- Induced osteoblast differentiation by amide derivatives of stilbene: The possible osteogenic agents
- On model selections for repeated measurement data in clinical studies
- Regulation of GLUT transporters by flavonoids in androgen-sensitive and -insensitive prostate cancer cells
- Region-specific microRNA signatures in the human epididymis
- Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety
- In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.