Corticosteroids inhibit the differentiation of U937 cells induced by the combination of lymphocyte-conditioned media and calcitriol
Abstract
Corticosteroids improve humoral hypercalcemia of malignancy in some patients presumably by decreasing osteoclast activity or number. Using the monoblastic U937 cell line as a model of osteoclast formation, it is shown that hydrocortisone (10(-6)M) and dexamethasone (10(-6)M) completely inhibited lymphokine-induced formation of mature, adherent cells. These changes were concentration dependent and specific for corticosteroids since neither progesterone nor 17 beta-estradiol produced similar effects. When used alone none of these hormones had toxic effects on U936 cells nor did they directly cause differentiation. These data are consistent with the possibility that in some types of humoral hypercalcemia of malignancy corticosteroids may work by inhibiting osteoclast formation from their precursors.
Read the paper
Related studies
- Development of a crushable foam model for human trabecular bone
- Data-driven motion compensation in HR-pQCT.
- Modeling of structure, quality, and function in the orthodontic patient
- Exploring the mechanism of Heidihuang Pill in the treatment of osteoporosis based on network pharmacology, molecular docking, and experimental validation
- Effect of fabric on the accuracy of computed tomography-based finite element analyses of the vertebra
- Use of interventions involving virtual reality tasks during the climacteric: a systematic review
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.